• In addition at the spinal level

  2021-11-11

  

  In addition, at the spinal level, results from colocalization experiments demonstrate that GABA-C receptors are present in the substantia gelatinosa and that they are presynaptically located. Neurons located in the substantia gelatinosa are differentially activated by afferent noxious and non-noxiou

• G quadruplex structures can be resolved by helicases

  2021-11-11

  

  G-quadruplex structures can be resolved by helicases. Consistently, many helicases are aberrantly expressed in cancer raf inhibitors [47]. In this study, we correlated HOXC10 expression with that of all helicases using a microarray dataset derived from 759 breast cancer patients [36] and discovered

• We have previously designed an azobenzene based molecule Raz

  2021-11-11

  

  We have previously designed an azobenzene-based molecule, Razo, which could switch the conformations of G-quadruplex structures by photoregulation. 12, 13, 14, 15 However, it lacks selectivity to different G-quadruplexes. Therefore, we want to find a way to modify this molecule so that it could be u

• Due to the presence of all FGFRs in

  2021-11-11

  

  Due to the presence of all FGFRs in the epithelium, there are several FGFs ligands that could be binding to these FGF receptors, namely FGFs 1–4, 8–10, 16 and 18–20. By evaluating the known roles of FGFs in epithelial-mesenchymal interactions and in bone development, this list can be reduced. For ex

• In general FPSs require Mg or Mn

  2021-11-11

  

  In general, FPSs require Mg2+ or Mn2+ as a cofactor for GPP and FPP synthesis. Co2+ also acts as a cofactor in EuFPSs, as in the case for PcFPS and Abies grandis FPS [29], [44]. Co2+ enhanced the activity of EuFPS1 more than the activity of EuFPS2: Mg2+, Mn2+ and Co2+ had approximately the same effe

• In terms of outcome measures

  2021-11-11

  

  In terms of outcome measures, statistically significant differences were only observed in need for invasive mechanical ventilation (23% vs 46%, p-value 0.005) and in-hospital mortality (13% vs 37%, p-value 0.002). Both these outcomes were still statistically significant following adjustment for conf

• The lysine K specific demethylase KDM family is

  2021-11-11

  

  The lysine (K)-specific demethylase 4 (KDM4) family is comprised of 4 isoforms, KDM4A to -D, also known as JMJD2A to -D. KDM4A, B, and C encode proteins consisting of a JmjC, a JmjN, two PHD, and two Tudor domains. KDM4D is unique within the KDM4 family in that it has neither PHD nor Tudor domains,

• The relationship between the attention deficit hyperactivity

  2021-11-11

  

  The relationship between the attention deficit hyperactivity disorder (ADHD) and H3Rs is supported by several reports (Berlin et al., 2011; Passani, Bacciottini, Mannaioni, & Blandina, 2000; Vohora & Bhowmik, 2012). ADHD is a neurobehavioral disorder with high prevalence in children, with hyperactiv

• There are several limitations in our study First only

  2021-11-11

  

  There are several limitations in our study. First, only the naturally occurring resistance-associated mutations in patients coinfected with HIV/HCV GSK 2830371 1b were analyzed. The result was only applicable to HCV genotype 1b, but not the HCV genotype 1a patients. We did not analyze the effect of

• The previous study demonstrated that

  2021-11-10

  

  The previous study demonstrated that the main CYP isoforms present in the human KNK437 included CYP46A1, 2J2, 2U1, 1B1, 2E1 and 2D6 (Dutheil et al., 2009b, 2010). CYP1B1 and CYP2U1 were found in the mitochondrial and microsomal fractions of astrocytes in the human frontal lobe, hippocampus, substan

• Several studies have indicated MUC to

  2021-11-10

  

  Several studies have indicated MUC1 to be an effective marker for identifying various malignant tumors, such as gastric, breast, pancreatic, ovarian, gallbladder, uterus, lung, and prostate cancers, as well as for prognostic outcomes [16], [17], [18], [19], [20], [21], [22], [23]. Studies by Kaira e

• L-AP5 Unlike our present results in week old months females

  2021-11-10

  

  Unlike our present results in 4–12-week-old (~1–3 months) females, where a high-fat-diet-induced increase in body weight was evident, Schmidt et al. exposed male glut3 mice to a similar high-fat diet (60% kilocalories from fat) and observed no change in body weight, plasma glucose or insulin concent

• directory br Acknowledgments br Introduction Postmenopausal

  2021-11-10

  

  Acknowledgments Introduction Postmenopausal osteoporosis, which is primarily caused by directory deficiency, has been a worldwide health problem and threatens postmenopausal women of all races. An estimated 80% of osteoporosis patients in the United States are women, and approximately 30% of p

• The identification of distinct expression domains in the lim

  2021-11-10

  

  The identification of distinct expression domains in the limb suggested that these domains might have specific biological functions. We explored this possibility by determining enriched biological processes for each category using GO ontology term analysis (WebGestalt) (Zhang et al., 2005). Category

• br Experimental br Results and discussions br Conclusion

  2021-11-10

  

  Experimental Results and discussions Conclusion Notes Introduction The noncanonical DNA structures that is, i-motif [[1], [2], [3], [4], [5], [6], [7], [8], [9]] and G-quadruplex [[10], [11], [12], [13], [14]] have recently been carefully studied using either experimental or computati

15885 records 536/1059 page Previous Next First page 上5页 536537538539540 下5页 Last page