• LPC OMe LPC LPC and OMe LPC were shown

  2022-05-21

  

  LPC 14:0, 2-OMe-LPC 14:0, LPC 16:0 and 2-OMe-LPC 16:0 were shown to be most potent stimulators of intracellular calcium flux in the β cell model, which is one of key processes leading to insulin exocytosis. Yet, species with myristoyl residue initiate calcium influx through voltage-gated cerdulatini

• SAR around amino derivative revealed a

  2022-05-21

  

  SAR around amino-derivative revealed a number of interesting trends related to the serum shift and in vitro activity (). A comparison of derivative , and its epimer , showed that the stereochemistry had little effect on the serum shift and the intrinsic affinity for the receptor. In contrast, re-p

• The combination of niacin with a selective

  2022-05-21

  

  The combination of niacin with a selective PGD2 receptor antagonist laropiprant, designed to circumvent the flushing side effect of niacin, has been evaluated in the HPS2-THRIVE study and showed no clinically meaningful benefit when administered in patients on top of statin therapy [41]. Our data su

• Through a large scale phylogenetic analysis

  2022-05-21

  

  Through a large-scale phylogenetic analysis of UDG superfamily in more than 1000 completely sequenced genomes, it is shown that family 3 Angiotensin 1/2 (1-5) can be separated into two clades with the traditional family 3 SMUG1 as one of them (Fig. 1) [31]. UDG enzymes in another clade are present i

• Although it is mainly a glial protein of

  2022-05-21

  

  Although it is mainly a glial protein, 5–10% of total GLT-1 represents a neuronal form located at presynaptic terminals, but its physiological role remains elusive (for discussion, see (Rimmele and Rosenberg, 2016)). Nevertheless, this amount might be significant since GLT-1 has been estimated to be

• 22 9 Gap junction intercellular communication GJIC facilitat

  2022-05-21

  

  Gap junction intercellular communication (GJIC) facilitates the exchange of ions, metabolites, Ca2+, inositol phosphates, and/or cyclic nucleotides of up to 1.8 kD in size between 22 9 through contact-dependent mechanisms [3,4]. Oocyte growth and development (as depicted in Fig. 1) depends, at leas

• Similarly Somavarapu and Kepp constructed a PS homology mode

  2022-05-21

  

  Similarly, Somavarapu and Kepp [29] constructed a PS1 homology model using 4HYG as a template, plus modeling the TM6-TM7 intracellular segment (amino acids 273 to 374). In this study, the authors considered for the first time the mature and immature (not autoproteolyzed) forms of PS1 component, sinc

• Clinical trials of all GSIs have ended prematurely

  2022-05-21

  

  Clinical trials of all GSIs have ended prematurely, raising the question on our understanding of their target, the γ-secretase/presenilin. Development of compounds to target γ-secretase and reduce Aβ production is complicated by the fact that γ-secretase/presenilin has critical biological function,

• Albumin is the major carrier of free fatty acids

  2022-05-21

  

  Albumin is the major carrier of free fatty acids (FFAs) in plasma [59], and harbours seven binding sites that are common to FFAs with a range of chain-lengths (C10-C18) across its three domains (Fig. 1a) [60,61]. In vitro, saturated, mono- and poly-unsaturated FFAs, with chain lengths ranging from C

• The ability of GPX and other selenoproteins to be

  2022-05-21

  

  The ability of GPX4 and other selenoproteins to be selectively induced by ferroptotic stimuli suggests that the stress-induced increase in the transcription of a number of putative, “antioxidant” selenoproteins is an adaptive homeostatic, but insufficient response to prevent cell death in the face o

• As for all DOACs measurement of

  2022-05-20

  

  As for all DOACs, measurement of DiXaIs activity requires the use of dedicated specific calibrators and controls. Each drug needs its own calibration and control material in a like to like manner. In no case can a drug concentration be extrapolated with the use of a calibrator established for anothe

• Our observation of LPS induced

  2022-05-20

  

  Our observation of LPS-induced increase in the sensitivity of cultured endothelium-intact coronary Nile Red towards stimulation with selective ETB receptor agonist (S6c) could be explained by activation of TLRs receptors located on the endothelium of rat coronary arteries. However, the possible rec

• The hyperacetylation of histone proteins

  2022-05-20

  

  The hyperacetylation of histone proteins by HATs is known to be associated with gene activation [51]. In particular, p300, which is a transcription factor having HAT activity, links activators to the transcription machinery at promoters [52]. The p300/CBP complex dynamically regulates hundreds of di

• br Hedgehog in chronic liver disease The liver

  2022-05-20

  

  Hedgehog in chronic liver disease The liver responds to different chronic insults with a highly conserved wound healing response during which different cell types must communicate to reconstruct fully functional, healthy liver parenchyma. The inter-cellular dialogue that orchestrates effective li

• So studies are currently in progress to design drugs which

  2022-05-20

  

  So, studies are currently in progress to design drugs which could inhibit the main crosstalk components between interacting key pathways (Fig. 1). Wnt The Wnt family consists of 19 highly conserved glycoproteins serving as ligands which bind to the G-protein coupled 7-pass transmembrane receptor

15862 records 419/1058 page Previous Next First page 上5页 416417418419420 下5页 Last page