matrix metalloproteinase The in vitro conditions for RA indu

2018-10-20

The in vitro conditions for RA-induced FP induction required high concentrations of RA, pointing possibly to an epiphenomenon that jump starts a self-enhancing activator/inhibitor signaling system, leading to localized FP formation. Both the FoxA2 gene, a transcription factor required for SHH expres

A key element of the

2018-10-20

A key element of the culture conditions is the balanced combination of growth factors and signaling molecules (e.g., EGF, bFGF, IGF, insulin, transferrin, and Rock inhibitor), which apparently generates an artificial androgen-independent PESC microenvironment that promotes the self-renewal and maint

Our study shows that iPSCs are highly proficient in antioxid

2018-10-20

Our study shows that iPSCs are highly proficient in antioxidant defense, which is presumably responsible for the low frequency of oxidative DNA lesions in both the mitochondrial and nuclear genome. Notably, previous non-quantitative proteomic studies revealed an abundant expression of antioxidant en

br Funding This work was funded by NIHR GM

2018-10-20

Funding This work was funded by NIHR01GM085456 awarded to Tanja Dominko. Declaration of interest The following are the supplementary data related to this article. Acknowledgements Introduction The identification of culture conditions that promote the expansion of primitive hematopoieti

Unlike the LMW FGF isoform which is

2018-10-20

Unlike the LMW FGF2 isoform, which is well-studied, the HMW isoforms of FGF2 are not nearly as well-understood, but recent reports have investigated the effects of HMW FGF2 signaling in various contexts. Localization of FGF2 isoforms can vary depending on cellular conditions and stimuli (Arese et al

br Experimental Procedures For detailed experimental procedu

2018-10-20

Experimental Procedures For detailed experimental procedures, see the Supplemental Experimental Procedures. Author Contributions Acknowledgments Introduction Cell transplantation in the central nervous system (CNS) requires exogenous cells to survive and integrate into the neural circui

As was shown in this study along with many other

2018-10-20

As was shown in this study, along with many other previous studies, TALEN and double-nicking CRISPR/Cas9 genome-editing techniques are significantly accurate, with only a negligible risk of random gene disruption, in the drug-selected clones. This result indicates that disrupting a particular gene w

br Results br Discussion The cognitive

2018-10-20

Results Discussion The cognitive deficits associated with prenatal VPA exposure might not due solely to the reduced neurogenesis with the abnormal neuronal morphology in the hippocampus, and there is a possibility that the low freezing responses in fear associative tests were contributed by th

Hello world!

2018-07-29