• br Experimental Procedures br Acknowledgments br Introductio

  2018-10-24

  

  Experimental Procedures Acknowledgments Introduction Spermatogonial stem droperidol Supplier (SSCs) give rise to the spermatogenesis that endures throughout the life of male animals (de Rooij and Russell, 2000; Meistrich and van Beek, 1993). SSCs reside in a special microenvironment termed

• Paper pools were established by

  2018-10-24

  

  Paper pools were established by searches of the PubMed database, which is accessible through the NIH National Library of Medicine (NIH/NLM). Data bank searches were performed separately to identify hESC- and hiPSC-related publications using the search strings described earlier (Guhr et al., 2006; Mü

• In this study lentiviral vectors were used

  2018-10-24

  

  In this study, lentiviral vectors were used to ablate CXCR4 and/or CXCR7 expression using shRNAs, and the derived hiPSC-CMs were tested for phenotypic and functional properties due to gene knockdown. Gene expression and flow cytometry studies confirmed the cardiomyocyte phenotype of the differentiat

• br Results br Discussion Frequent tumor relapse in multiple

  2018-10-24

  

  Results Discussion Frequent tumor relapse in multiple tumor types has now been attributed to the presence of residual CSCs after conventional treatments. We and others have previously identified CD133 to mark a liver CSC subpopulation in HCC (Ma et al., 2007, 2010). Yet, the functional paths b

• The analysis of skeletal muscle regeneration and

  2018-10-24

  

  The analysis of skeletal muscle regeneration and SC self-renewal following transplantation indicated that huSCs expanded in the presence of p38i exhibited tissue regenerative and self-renewal potential exceeding that of even freshly isolated quiescent huSCs. Given that quiescent huSCs are no more di

• The NT formation and NESC to RGPCs transition

  2018-10-24

  

  The NT formation and “NESC-to-RGPCs” transition at the onset of neurogenesis are two fundamental events in the early developing glutamate receptor antagonist (Götz and Huttner, 2005). However, the developmental regulations are unclear due to being hard to definitely control the two stages. In this

• The first consistency check we performed was that the normal

  2018-10-24

  

  The first consistency check we performed was that the “normal metabolism” scenario, defined as baseline HDM activity and lack of induction of stemness transcription factors, should lead to cell differentiation. Figure 1B shows that, after an initial transient regime, the system settles down to a ste

• HSC functions are severely compromised following acute

  2018-10-24

  

  HSC functions are severely compromised following acute and chronic TLR4 activation (Esplin et al., 2011; Rodriguez et al., 2009). We demonstrated that TRIF signaling is a critical mediator of HSC injury, since its deletion fully restores HSC functions following LPS exposure. Transplantation of LPS L

• Whether LIF contributes to differentiation inhibition in rab

  2018-10-24

  

  Whether LIF contributes to differentiation inhibition in rabbit PSCs is unclear. LIF and FGF2 cooperatively support self-renewal in ESCs derived from parthenogenotes and propagated in feeder-free conditions, but the effect of LIF is modest (Hsieh et al., 2011). In this study, AKSL and AKSgff cell li

• Transplantation of RPE cells may be a treatment

  2018-10-24

  

  Transplantation of RPE cells may be a treatment for retinal diseases, such as age-related macular degeneration (AMD). Many experimental clinical applications of allogeneic RPE cells for the treatment of AMD have been attempted (Algvere, 1997; Algvere et al., 1999; Kaplan et al., 1999; Peyman et al.,

• br Results br Discussion The data presented herein

  2018-10-24

  

  Results Discussion The data presented herein substantially expand the potential of developing CSC-targeted therapy based on inhibition of the SUMO pathway. We show that inhibition of sumoylation by knockdown of UBC9 and PIAS1 effectively repressed expression of MMP14 and CD44, reduced invasive

• In the present study we demonstrated the potential of hiPSC

  2018-10-24

  

  In the present study, we demonstrated the potential of hiPSC-CMs to reflect an adverse drug response in healthy individuals. However, as mentioned above, studies in larger cohorts of individuals and using various types of drugs will be required to translate this prostaglandin receptor potential into

• What is more intriguing is that non MNs undergo

  2018-10-24

  

  What is more intriguing is that non-MNs undergo degeneration earlier than MNs. This is demonstrated by the fact that loss of non-MNs is already obvious in the spinal cord segment that is distant from the injection site and has partial (ventral gray matter) integration by human astrocytes. Unlike the

• Although it remains unclear how

  2018-10-24

  

  Although it remains unclear how aPKCi promotes intermediate neurogenesis in the context of our “MGE” differentiation system, there are several intriguing possibilities. First, the aPKC subgroup contains two isoforms, iota (ι or λ) and zeta (ζ), which have been shown to have numerous, distinct functi

• Stem cell research and the

  2018-10-24

  

  Stem cell research and the ISSCR have undergone enormous growth over the past 15 years, as evidenced by the strength of basic research programs, industry, and clinical trials that are pioneering the field of regenerative medicine. As the ISSCR celebrates its milestone 15th anniversary, we ask for yo

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