• The hippocampus is the primary brain

  2024-07-15

  

  The hippocampus is the primary brain structure involved in learning and memory. The role of hippocampal synaptic plasticity in neurological processes in cognition and depression has been extensively demonstrated. Synaptophysin is a critical substance in synaptogenesis, which is necessary for learnin

• HT modulates cortical and hippocampal pyramidal

  2024-07-15

  

  5-HT modulates cortical and hippocampal pyramidal cell function in a very complex manner, since most 5-HT receptor subtypes (excitatory as well as inhibitory) are expressed on pyramidal PX-478 2HCl as well as GABAergic interneurons that exert inhibitory control over pyramidal cells (Leiser et al.,

• In brief serotonin can interact with classes of receptors

  2024-07-15

  

  In brief, serotonin can interact with 7 classes of receptors are differentiated into 14 subtypes (Barnes and Sharp, 1999). Specifically, 5-HT1A and 5-HT2C receptors have been the most widely studied in the modulation of anxiety responses (Deakin et al., 1992; Millan, 2003). However, the studies that

• L002 receptor The srd a isoforms showed unique

  2024-07-15

  

  The srd5a isoforms showed unique expression profiles in early FHM development (Fig. 2). Similar to amphibian embryos, there was a high abundance of both srd5a1 and srd5a3 at 1dpf in FHMs, suggesting that mRNA for these enzymes may be maternally deposited and that these enzymes may play a key role in

• br Material and methods br

  2024-07-15

  

  Material and methods Results Discussion Clinical gene therapy trials with viral vectors have been in use for treatment of various genetic disorders and diseases, however efficacious, targetable and highly reliable non-viral delivery systems are needed for safe and long-term applications. De

• exendin 4 br Acknowledgments br Introduction Cancer is the l

  2024-07-15

  

  Acknowledgments Introduction Cancer is the leading cause of mortality in the United States for those between the ages of 40–79 years, surpassing heart diseases by more than 100,000 deaths [1]. The cause of most cancer subtypes remains idiopathic and may arise out of ‘bad luck’ among otherwise

• Skeletal pain associated with bone fracture is another

  2024-07-15

  

  Skeletal pain associated with bone fracture is another area of critical need for a novel pain medication. NSAIDs and opiates are the two major therapies currently used to manage bone fracture pain. However, both of these therapies lead to significant unwanted side effects. Using the osteotomy model

• To identify the kinase s mediating H S phosphorylation we

  2024-07-15

  

  To identify the kinase(s) mediating H3.3S31 phosphorylation, we devised a 96-well-plate-compatible immunostaining assay, with GSK126 specific for H3.3S31ph, and utilized it to screen both a Qiagen siRNA library covering 720 human kinases and a kinase inhibitor library (Selleck) containing 194 compo

• 23 The downstream targets of ATR involved

  2024-07-15

  

  The downstream targets of ATR involved in mediating human telomerase recruitment have not yet been identified. Under stalled fork conditions, activated ATR is able to phosphorylate and activate ATM (Stiff et al., 2006, and Figures 4C and 4D); whether this 23 of ATM participates in a positive feedba

• br Consequences of central apelin APJ

  2024-07-12

  

  Consequences of central apelin/APJ modulation Regarding extra-hypothalamic actions, recent data demonstrate that the central apelin/APJ system could be a potential new target for the regulation of memory (Han et al., 2014). Then, intracerebroventricular (icv) apelin administration in mice impairs

• br Acknowledgments br Protein microarrays were

  2024-07-12

  

  Acknowledgments Protein microarrays were developed to provide miniaturized high-throughput tools to study protein function, induced pluripotent stem cells and post-translational modifications. Just a few years ago, the seminal work performed in Stuart Schreiber's laboratory at Harvard Universit

• MSG model is well characterized

  2024-07-12

  

  MSG model is well characterized and widely used because it is not influenced by dietary components and because it mimics a lesion in the arcuate nucleus and lateral hypothalamus that can occur in chronic obese patients (Moraes et al., 2009, Purkayasta and Cai, 2013). High fat fed diet is amongst the

• TAI-1 Introduction Lipoxygenases LOXs are key enzymes that c

  2024-07-12

  

  Introduction Lipoxygenases (LOXs) are key enzymes that catalyze the polyunsaturated fatty acids (PUFAs) such as arachidic TAI-1 (AA), linoleic acid (LA) and others unsaturated fatty acids (Brash, 1999). LOXs are expressed in immune, neural, epithelial, tumor cells and other cells (Claesson, 2009).

• The present study determined the effect of DCA on

  2024-07-12

  

  The present study determined the effect of DCA on VSMC calcification in vitro and in atherosclerotic ApoE-/- mice in vivo. We found that (R)-baclofen receptor non-toxic concentrations of DCA, did not affect VSMC viability, induced calcification of VSMC in culture and increased atherosclerotic vascu

• In the past few years several experimental findings

  2024-07-12

  

  In the past few years, several experimental findings have demonstrated a pivotal involvement of adenosine also in driving the phenotypic switch of macrophages. In particular, the stimulation of A2A and A2B receptors seems to play a critical role in switching macrophages from M1 to M2 phenotype [37,6

15187 records 68/1013 page Previous Next First page 上5页 6667686970 下5页 Last page