• br Introduction Human immunodeficiency virus HIV is

  2022-04-02

  

  Introduction Human immunodeficiency virus-1 (HIV-1) is a retrovirus that primarily infects components of the human immune system, such as CD4+ T cells, macrophages and dendritic Biotin-HPDP australia (Clapham and McKnight, 2001). HIV directly and indirectly destroys CD4+ T cells, which leads to s

• We recently reported that the human derived

  2022-04-02

  

  We recently reported that the human-derived PancCa cell line PANC-1 and the human-derived hepatocellular HepG2 cell line express GPR55 mRNA and protein [21]. In PANC-1 and HepG2 cells, knockdown of GPR55 with specific siRNAs abrogates cellular uptake of Tocrifluor 1117, a selective GPR55 ligand [21]

• GPR agonistic activity was evaluated for the human GPR recep

  2022-04-02

  

  GPR119 agonistic activity was evaluated for the human GPR119 receptor in a cell-based cAMP assay. The results expressed the potency as EC values and the inherent activity (IA) as percentages which were compared to the test compound with oleoylethanolamide (OEA), an endogenous ligand of GPR119 (defin

• Glutamate aspartate transporters or excitatory amino acid tr

  2022-04-01

  

  Glutamate-aspartate transporters or excitatory amino valdecoxib sale transporters (EAATs) are essential for the maintenance of glutamate homeostasis. EAATs are widely distributed in central neurons and glial cells (Danbolt, 2001, Martinez-Lozada et al., 2011). They are driven by Na + and K+ gradien

• Peripheral injury or disease induced alterations in synaptic

  2022-04-01

  

  Peripheral injury- or disease-induced alterations in synaptic efficacy occur not only at the first synapse made by the primary nociceptive afferents in the spinal dorsal horn but are also operational in several regions processing the sensorimotor as well as emotional-affective components of pain, su

• br Materials and methods br Results br Discussion Here

  2022-04-01

  

  Materials and methods Results Discussion Here, we investigated the inhibitory effects and associated mechanisms of phloroglucinol on α-glucosidase. Our results showed that phloroglucinol reversibly inhibited α-glucosidase in a dose-dependent manner (Fig. 1), with the double-reciprocal plot

• gsk525762 In the present study we tested glucosidase

  2022-04-01

  

  In the present study, we tested α-glucosidase and tyrosinase inhibitory effects of the methanol extract from lower stems and gsk525762 of Q. coccifera (1) as well as the isolated compounds [lyoniresinol-9-O-β-xylopyranoside (2) and lyoniresinol-9-O-β-glucopyranoside (3), cocciferoside (4), (-)-8-ch

• Epinephrine responses to hypoglycemia are probably triggered

  2022-04-01

  

  Epinephrine responses to hypoglycemia are probably triggered centrally, perhaps with input from peripheral hypoglycemia sensing [3], [4]. We observed increased epinephrine responses in GCK-MODY and I366F diabetic mice. Consistent with a role for 5823 synthesis GCK in detecting a low blood glucose,

• br Introduction Maintaining blood glucose within an appropri

  2022-04-01

  

  Introduction Maintaining blood glucose within an appropriate range is crucial for survival. In diabetes, those who suffer episodes of severe hypoglycemia have an increased risk of death [1], [2]. The nefiracetam is especially dependent on an adequate, continuous supply of circulating glucose to f

• br Introduction Calorie restriction CR

  2022-04-01

  

  Introduction Calorie restriction (CR), in the absence of malnutrition, has beneficial effects on prostaglandin e2 function, including reducing the incidence of age-related neurodegenerative disease (Gräff et al., 2013), eliciting anti-depressant behavior (Lutter et al., 2008) and improving memor

• Newt GHS R a proteins expressed in a mammalian cell

  2022-04-01

  

  Newt GHS-R1a proteins expressed in a mammalian cell were able to bind homologous newt ghrelin, heterologous rat and bullfrog ghrelin, and a peptidyl GHS-R1a agonist, GHSRP-6, with inducing intracellular Ca signaling. This indicates that the identified cDNA encodes the ghrelin receptor from a view of

• br Materials and methods br

  2022-04-01

  

  Materials and methods Results Discussion BTB, as a necessary structure for the spermatogenic epithelium, provides an important internal environmental for spermatogenesis and its disruption leads to male infertility (Qiu et al., 2016). GJs and TJs which are mainly components of BTB play esse

• The conversion of lactose to GOS

  2022-04-01

  

  The conversion of lactose to GOS by β-gal involves the same transglycosylation mechanism used by most glycoside hydrolases (GHs). This mechanism (Fig. 1) involves an enzyme-bound intermediate and consists of two processes: glycosylation and deglycosylation (Adlercreutz, 2017). The glycosylation proc

• Astemizole australia NMDARs are glutamate gated ionotropic r

  2022-04-01

  

  NMDARs are glutamate-gated ionotropic receptors that are involved in excitatory neurotransmission and plasticity (Traynelis et al., 2010). There have been several reports showing that neurosteroids acting as negative modulators of NMDARs exert neuroprotective activity in both in vitro and in vivo mo

• Introduction Initially postulated to represent the main

  2022-04-01

  

  Introduction Initially postulated to represent the main source of ATP production in eukaryotic cells, mitochondria are recently recognized to perform manifold essential functions beyond energy production, impacting most areas of cell biology and medicine [1]. Mitochondrial metabolism is both the ba

15239 records 404/1016 page Previous Next First page 上5页 401402403404405 下5页 Last page